Periodontitis Is Associated With Serum Prostate Specific Antigen Concentrations in <scp>C</scp> hinese Male

OBJECTIVE: This study aimed to clarify the association between periodontitis and prostate-specific antigen and to guide the early prostate-specific antigen screening of periodontitis patients. MATERIALS AND METHODS: 1409 participants who visited West China Hospital of Sichuan University during 2021 and 2022 were included. Measurements were taken for blood pressure, fasting blood glucose, total cholesterol, triglycerides, C-reactive protein, carcinoembryonic antigen, and prostate-specific antigen. Participants went through periodontal examinations and were grouped into non-periodontitis individuals, mild periodontitis, moderate periodontitis, and severe periodontitis. Logistic regression was used to explore the potential associations. RESULTS: Patients with severe periodontitis had significantly higher serum prostate-specific antigen compared to non-periodontitis individuals. No significant association between periodontitis and prostate-specific antigen was found in participants aged 20-40. In patients aged 41-80, regression models showed a significant association between elevated prostate-specific antigen and severe periodontitis, which was not significant in patients with mild and moderate periodontitis. CONCLUSION: In Chinese men aged 20-80 years, serum prostate-specific antigen was significantly higher in patients with severe periodontitis than in non-periodontitis patients. Severe periodontitis was significantly associated with elevated PSA levels among elder patients.