New transcription signals in SARS-CoV-2 reshape virus–host interactions

Non-spike changes driving SARS-CoV-2 fitness remain undercharacterized. Two PLOS Biology papers show that evolutionary N gene changes create a transcription-regulating sequence producing a truncated N protein that enhances fitness by blocking antiviral responses.

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Publication Details

Journal
PLoS Biology
Published
2026-04-17
DOI
https://doi.org/10.1371/journal.pbio.3003744
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00
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article

New transcription signals in SARS-CoV-2 reshape virus–host interactions

Isabel Sola, Sonia Zuñiga
PLoS Biology
SARS-CoV-2 and COVID-19 Research
article

New transcription signals in SARS-CoV-2 reshape virus–host interactions

Isabel Sola, Sonia Zuñiga
article en

Abstract

Non-spike changes driving SARS-CoV-2 fitness remain undercharacterized. Two PLOS Biology papers show that evolutionary N gene changes create a transcription-regulating sequence producing a truncated N protein that enhances fitness by blocking antiviral responses.

PLoS BiologyVol. 24(4)
Centro Nacional de Biotecnología (ES), Universidad Autónoma de Madrid (ES)
Zero hunger
Openalex Percentile: Top 17%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
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New transcription signals in SARS-CoV-2 reshape virus–host interactions — Isabel Sola, Sonia Zuñiga · PLoS Biology (2026) | TGRS Research Map | TGRS