TNF-α Polymorphisms in Major Depressive Disorder in Patients with and Without Cardiovascular Disease: A Systematic Review
promoter polymorphisms in major depressive disorder. These variants may exert context-dependent modulatory effects on symptom expression, treatment response, or inflammatory-cardiovascular interactions rather than serving as primary susceptibility determinants. Larger, ethnically diverse studies integrating genetic, inflammatory, and clinical data are required to clarify the contribution of inflammatory genetic variability in depressive disorders.
Authors
- Izabel Cristina Rodrigues da Silva (ORCID: https://orcid.org/0000-0002-6836-3583)
- CAROLINE FERREIRA FRATELLI
- Antonio Avelino Ferreira Soares (ORCID: https://orcid.org/0000-0003-2364-1014)
- Bruna Rodrigues Gontijo (ORCID: https://orcid.org/0000-0001-6662-7138)
- Larissa Sousa Silva Bonasser (ORCID: https://orcid.org/0000-0002-7812-8026)
- Calliandra Maria de Souza Silva (ORCID: https://orcid.org/0000-0002-9064-0735)
- Alexandre Sampaio Rodrigues Pereira (ORCID: https://orcid.org/0000-0001-9126-8747)
- Dante Mafra Tourino Teixeira
- Yago Rodrigues Gontijo (ORCID: https://orcid.org/0009-0005-1254-5328)
Institutions
- Universidade de Brasília (BR)
- Universidade Federal de Campina Grande (BR)
- Centro Universitário de Caratinga (BR)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/biomedicines14040922
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Apoio à Pesquisa do Distrito Federal