Granulocyte colony stimulating factor for acute myocardial infarction: an updated systematic review and meta-analysis of randomized controlled trials
INTRODUCTION: Granulocyte Colony-Stimulating Factor (G-CSF) has been explored as a therapy to enhance myocardial repair after acute myocardial infarction (AMI). Earlier meta-analyses of randomized controlled trials (RCTs) reported no significant improvement but recently published studies warranted an updated synthesis. METHODS: We searched PubMed, Embase, Cochrane Library, and Web of Science for RCTs comparing G-CSF with placebo or standard care in AMI. Primary outcomes were left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and left ventricular ejection fraction (LVEF). Secondary outcomes were mortality, reinfarction, restenosis, and revascularization. RESULTS: = 0.947). LVESV showed no significant differences. No effects were seen for mortality, reinfarction, restenosis, or revascularization. CONCLUSION: G-CSF may confer structural benefits detectable by echocardiography, yet clinical outcomes remain unchanged. Larger, high-quality trials are needed to define its therapeutic role.
Authors
- Rafael Torres Fonseca dos Santos (ORCID: https://orcid.org/0009-0001-3698-8845)
- Fernanda Almeida Andrade (ORCID: https://orcid.org/0000-0002-2612-8040)
- Lucca Tamara Alves Carretta (ORCID: https://orcid.org/0009-0005-1942-2363)
- Mariana Oliveira (ORCID: https://orcid.org/0009-0006-2091-1567)
- Luciano Falcão (ORCID: https://orcid.org/0000-0003-4521-9041)
- Luiz Guilherme Silva Almeida (ORCID: https://orcid.org/0009-0008-4476-1174)
- Yasmin Picanço Silva (ORCID: https://orcid.org/0009-0003-5728-4964)
- Karlos Daniell Araújo dos Santos (ORCID: https://orcid.org/0000-0002-6592-4023)
- Gustavo Surgik
- Ricardo F.O Suruagy-Motta
- Adolfo Moraes de Souza (ORCID: https://orcid.org/0000-0002-0786-5571)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Pontifícia Universidade Católica do Paraná (BR)
- Universidade Católica de Brasília (BR)
- Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória (BR)
- Centro Universitário Cesmac (BR)
- Universidade Federal de Roraima (BR)
- Centro Universitário Carioca (BR)
- Family Healthcare (US)
- Universidade Federal de São Paulo (BR)
- University of Rio Grande and Rio Grande Community College (US)
Publication Details
- Journal
- Future Cardiology
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1080/14796678.2026.2655394
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00