<b>Title:</b> DAP-Seq Reveals Cluster-Situated Regulator Control of Numerous <i>Streptomyces</i> Natural Product Biosynthetic Genes
strains. qsCSRs in this cohort exert influence across multiple cellular processes, with particularly strong impacts on other transcription factors throughout the genome. Approximately 30% of predicted NP BGCs contained qsCSR-regulated genes. In strains encoding multiple qsCSRs, we observed substantial overlap in the BGC regulation. Together, these results greatly expand the genomic landscape of qsCSR activity and provide a foundation for improved bioinformatic strategies to predict and interpret the regulatory control of NP biosynthesis.
Authors
- Y Zhang
- Nicolas Grosjean (ORCID: https://orcid.org/0000-0002-8146-7862)
- Elizabeth I. Parkinson (ORCID: https://orcid.org/0000-0002-3665-5522)
- i Blaby
- Elliot Brajkovich
- Lauren E. Wilbanks
- Leo Baumgart
Institutions
- Lawrence Berkeley National Laboratory (US)
- Joint Genome Institute (US)
- Purdue University West Lafayette (US)
- Tarpo (Czechia) (CZ)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c01605
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Purdue University
- Purdue Research Foundation
- Purdue University Center for Cancer Research
- Joint Genome Institute
- National Cancer Institute
- Division of Chemistry