Propranolol alleviates cerebral infarction through the β2-AR-mediated ERK/NLRP3 pathway
-ERK1/2 and NLRP3 in BV2 cells. Furthermore, U0126 treatment also lowered NLRP3 and IL-1β levels. These results demonstrated the important role of β2-AR signaling in regulating the inflammatory response in ischemic stroke.
Authors
- Xue-Ting Liu
- Lei Zuo (ORCID: https://orcid.org/0000-0002-6390-5590)
- Fan Geng (ORCID: https://orcid.org/0000-0001-9809-7688)
- Tianxiao Li (ORCID: https://orcid.org/0000-0001-5503-5743)
- Meng‐Meng Zhu
- Zhi-Jun Zhang
- Xiu Chen
- Qing-Guo Ren
- Na Zhao
Institutions
- Zhongda Hospital Southeast University (CN)
- Southeast University (CN)
Publication Details
- Journal
- iScience
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1016/j.isci.2026.115779
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province