Precise Modulation of Excited‐State Energy Flow via Consecutive Twisted Intramolecular Charge Transfer (ConTICT) for Autophagy‐Blocking Photothermal Therapy
). Furthermore, it induces disruption of lysosomal structures, and blocks autophagy processes. Upon encapsulation into liposomes, the photothermal agent exhibits specific tumor site targeting, enables fluorescence/photothermal/photoacoustic trimodal deep-tissue imaging, and delivers robust in vivo antitumor therapeutic efficacy. This work presents a generalizable molecular strategy for precisely manipulating quantum energy flow to construct next-generation phototheranostics.
Authors
- Fuping Han
- X D Li
- Jiangli Fan (ORCID: https://orcid.org/0000-0003-4962-5186)
- Wen Ce Sun (ORCID: https://orcid.org/0000-0003-4316-5350)
- Saran Long (ORCID: https://orcid.org/0009-0005-3860-6854)
- Hongyi Zhang
- Xiaojun Peng (ORCID: https://orcid.org/0000-0002-8806-322X)
- Kaifeng Wu (ORCID: https://orcid.org/0000-0002-1047-6606)
- Jianjun Du (ORCID: https://orcid.org/0000-0001-7777-079X)
Institutions
- Ningbo University of Technology (CN)
- Dalian Institute of Chemical Physics (CN)
- Shenzhen University (CN)
- Dalian University of Technology (CN)
- Dalian University (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1002/anie.7561107
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities