Discovery of INCB191358: A Potent and Selective DGKα/ζ Dual Inhibitor
achieved transient, yet highly efficacious target coverage, inducing antigen-dependent T-cell activation in a mouse pharmacodynamic model and enhancing antitumor efficacy in a syngeneic tumor model when combined with PD-1 blockade.
Authors
- Sunkyu Kim (ORCID: https://orcid.org/0000-0002-0240-6210)
- Jacob J. Lacharity
- Michelle Frascella
- Melissa Chan (ORCID: https://orcid.org/0000-0003-3605-4644)
- Liana Hie (ORCID: https://orcid.org/0000-0002-5196-8260)
- Bihui Melidosian
- Lisa Truong (ORCID: https://orcid.org/0000-0003-1751-4617)
- 钱定权
- Xiaozhao Wang (ORCID: https://orcid.org/0009-0002-0257-4393)
- Xiaodi Ren
- Kelly Federowicz
- Joshua R. Hummel (ORCID: https://orcid.org/0009-0001-9077-2076)
- Rodrigo Hess
- Gengjie Yang
- Maryanne Covington
- Patrick Mayes
- Jeff Jackson
- Bo Wei
- David Rodrigues
- Xiaolei Li
- Guofeng Zhang
Institutions
- Incyte (United States) (US)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03768
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Incyte