Granzyme B-expressing regulatory B cells share the same origin as conventional blood B cells
Bregs likely arise from the conventional mature B cell pool and represent a differentiation state shaped by environmental cues rather than constituting a distinct clonal lineage.
Authors
- Karin Tarte (ORCID: https://orcid.org/0000-0002-6809-917X)
- Marie Cornic
- Michel Cogné (ORCID: https://orcid.org/0000-0002-8519-4427)
- Steve Genebrier (ORCID: https://orcid.org/0000-0002-6353-5497)
- Samuel Bastos Serra Trinca
- Hoa Le Mai (ORCID: https://orcid.org/0000-0003-2099-4420)
- Magali Giral
- Richard Danger
- Nicolas Sailliet
- Sophie Brouard
- Amandine Dupuy (ORCID: https://orcid.org/0009-0008-3891-5253)
Institutions
- Inserm (FR)
- Institut de Transplantation Urologie en Nephrologie (FR)
- Établissement Français du Sang (FR)
- Microenvironment and B-cells: Immunopathology, Cell, Differentiation and Cancer (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1016/j.bbrep.2026.102594
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Etablissement Français du Sang