Obesity as the Upstream Driver of Inflammation and Insulin Resistance in Hyperuricaemia

reported that systemic inflammation (modified inflammation [mINFLA] score) and insulin resistance (triglycerideglucose [TyG] index) are independently and jointly associated with hyperuricaemia (HUA) risk, with the TyG index mediating approximately 15% of the inflammation-HUA relationship.The authors provide a thorough analysis of these interacting pathways.This correspondence proposes that for a substantial subset of individuals with overweight or obesity, adiposity may function not as another concurrent pathway but as the unifying upstream driver of both inflammation and insulin resistance in HUA.