Light‐Induced Chiral Aldehyde/Palladium Catalysis‐Enabled Asymmetric Allylic C─H Alkylation of Alkenes With NH <sub>2</sub> ‐Unprotected Amino Acid Derivatives
-unprotected amino acid esters. The results demonstrate that competing allylic C-H amination is completely suppressed, and the desired alkylation products-bearing either allyl or conjugated enyne moieties-are obtained in 32%-93% yields with 80%-98% ee values. Mechanistic studies reveal that enantiocontrol is achieved through the cooperative action of the chiral aldehyde and the chiral ligand, and the latter primarily dictates the absolute configuration of the product by forming noncovalent C-H···π and C-H···O interactions with the chiral aldehyde-involved Zn complex.
Authors
- Zhu‐Lian Wu (ORCID: https://orcid.org/0000-0001-8444-4028)
- Shao‐Fei Ni (ORCID: https://orcid.org/0000-0001-9860-2138)
- B. Yao (ORCID: https://orcid.org/0000-0002-7499-5202)
- Wei Wen
- Qi‐Xiang Guo (ORCID: https://orcid.org/0000-0002-0405-7958)
- H.‐P. GUAN
- Tian Cai
Institutions
- Southwest University (CN)
- Shantou University (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1002/anie.1471995
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southwest University