Systematic Review of Mammalian Models for Experimental Sporotrichosis: Pathogenesis, Methodological Variables, and Ethical Considerations
was the most widely used species, considering both the entire period (1900-2024: 77.11%) and the period after the description of new species (2008-2024: 56.47%). Animal welfare conditions were poorly detailed in all articles. Only four studies reported a humane endpoint to terminate the experiment, and one presented consideration of the 3Rs (Replace, Reduce, and Refine). A few articles mentioned the most significant criteria grouped to evaluate the pathogenicity/virulence of the fungal species studied.
Authors
- Cíntia de Moraes Borba (ORCID: https://orcid.org/0000-0003-3210-0623)
- Thais Guimarães Barreira
- Manoel Marques Evangelista Oliveira (ORCID: https://orcid.org/0000-0001-7670-9225)
- Danielly Corrêa-Moreira (ORCID: https://orcid.org/0000-0002-0931-4204)
- Rodolfo Castro
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Faculdades Oswaldo Cruz (BR)
- Escola Nacional de Saúde Pública (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Animals
- Published
- 2026-04-17
- DOI
- https://doi.org/10.3390/ani16081226
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro