Cationic Polymer–Photothermal Agent Conjugates with Enhanced Light Absorption and Tumor Accumulation for Efficient Phototherapy of Osteosarcoma
), we have successfully engineered multifunctional nanoparticles that facilitate efficient in situ enrichment of osteosarcoma via active endocytosis. Furthermore, molecular self-assembly reduces the size of the nanoparticles and diminishes the interactions between aza-BODIPY molecules within the polymer matrix, markedly improving the light absorption efficiency of the nanoparticles. This cationic polymer-photothermal agent conjugate design not only amplifies the fluorescence brightness of the nanoparticles but also enhances the photothermal therapy (PTT) efficacy against in situ osteosarcoma.
Authors
- Z Liu
- Tianxiang Wu (ORCID: https://orcid.org/0000-0003-0778-0380)
- Junyan Zheng (ORCID: https://orcid.org/0000-0002-3097-1225)
- Zhenxiong Shi
- Zhenshuang Du
- Jun Qian (ORCID: https://orcid.org/0000-0003-2131-3885)
- Weiling He (ORCID: https://orcid.org/0000-0003-4061-7382)
- Renhao Ding
- Shuai Li
Institutions
- American Institute of Biological Sciences (US)
- Xiamen University (CN)
- Shanghai Optical Instrument Research Institute (CN)
- Heinz Optical Engineering (United States) (US)
- Zhejiang University (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2026-04-17
- DOI
- https://doi.org/10.1021/acsnano.5c21936
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Fujian Province
- Xiamen University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Basic and Applied Basic Research Foundation of Guangdong Province