The Effect of Liraglutide on the Hypolipidemic, Anti-Inflammatory, and Antioxidant Properties of Atorvastatin Mediated via the Nrf2/HO-1 Signaling Pathway: In Vivo and In Silico Validation
: Our findings support targeting the Nrf2/HO-1 signaling pathway as a potential therapy for reversing hyperlipidemia and preventing mediators of inflammation and oxidative stress damage in the liver tissue. The evidence of increased efficacy observed with the combined atorvastatin and liraglutide supports a potential novel understanding of the complementary effects of atorvastatin and liraglutide. This finding requires further investigation to elucidate the combination's therapeutic advantages in treating metabolic disorder scenarios.
Authors
- Samah J. Almehmadi (ORCID: https://orcid.org/0000-0002-6014-3148)
- Tarek A. Yousef (ORCID: https://orcid.org/0000-0003-3039-7646)
- Abdullah Al-Dakhil (ORCID: https://orcid.org/0000-0002-3193-7328)
- Tahani Mohamed Ibrahim Al-Hazani
- Maha Alhelf (ORCID: https://orcid.org/0000-0002-8648-360X)
- Yosra Magdy (ORCID: https://orcid.org/0000-0002-1226-3057)
- Tamer M. M. Abu-Amara (ORCID: https://orcid.org/0000-0003-4326-3663)
- Mortaga M. Abou–Krisha (ORCID: https://orcid.org/0000-0003-2224-8165)
- Sherif A. Kamar (ORCID: https://orcid.org/0000-0002-3682-869X)
- Eman Serry Zayed
- Sara Khedr
- Amina A. Sedky
Institutions
- Al-Ahliyya Amman University (JO)
- Ain Shams University (EG)
- Prince Sattam Bin Abdulaziz University (SA)
- Cairo University (EG)
- Al-Azhar University (EG)
- Umm al-Qura University (SA)
- Imam Mohammad ibn Saud Islamic University (SA)
- Nile University (EG)
- University of Tabuk (SA)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/pharmaceutics18040490
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00