Higher 25(OH)D Levels at Admission Predict a Favorable Disease Evolution in Moderate-to-Severe COVID-19 Patients
= 0.0446) compared with all other patients. Through multivariable logistic regression analysis, higher 25(OH)D levels at the time of hospitalization were confirmed as an independent predictor of favorable outcome. A plasma 25(OH)D concentration above 11.10 ng/mL predicted favorable disease resolution, with a positive likelihood ratio of 1.40 (IQR: 1.05-1.87). In conclusion, our findings support plasma vitamin D levels as an independent predictor of clinical outcomes in patients hospitalized with COVID-19 pneumonia.
Authors
- Martina Costanzo (ORCID: https://orcid.org/0000-0002-1042-2982)
- Manuela Rizzi (ORCID: https://orcid.org/0000-0002-6174-7111)
- Erica Matino (ORCID: https://orcid.org/0000-0002-2501-6645)
- Pier Paolo Sainaghi (ORCID: https://orcid.org/0000-0001-8322-9158)
- Veronica Vassia (ORCID: https://orcid.org/0000-0002-7097-0710)
- Donato Colangelo (ORCID: https://orcid.org/0000-0003-2277-3226)
- Erika Zecca (ORCID: https://orcid.org/0000-0003-2134-6986)
- Stelvio Tonello (ORCID: https://orcid.org/0000-0002-0836-0890)
- Giuseppe Francesco Casciaro (ORCID: https://orcid.org/0000-0003-1420-4058)
- Luigi Mario Castello (ORCID: https://orcid.org/0000-0001-8248-1976)
- Paolo Amedeo Tillio (ORCID: https://orcid.org/0000-0003-4451-038X)
- Roberta Rolla (ORCID: https://orcid.org/0000-0003-0805-8285)
- Raffaella Landi (ORCID: https://orcid.org/0000-0003-0492-553X)
- Francesca Boccafoschi (ORCID: https://orcid.org/0000-0002-6734-5447)
- Mario Pirisi (ORCID: https://orcid.org/0000-0001-9740-0155)
- Alessandro Croce (ORCID: https://orcid.org/0000-0003-3547-1913)
- Eleonora Rizzi (ORCID: https://orcid.org/0000-0001-9615-2452)
- Federica Vincenzi
- Iris Zeqaj
- Umberto Dianzani
- Anita Pedrinelli
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/ijms27083541
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute