LINC02470 impairs natural killer cell cytotoxicity by epigenetically targeting the natural cytotoxicity triggering receptor 1

Introduction: Natural killer cells (NK cells) play a critical role in the surveillance of tumor immunity. However, NK cell-based immunotherapy, including autologous and allogeneic NK cell reinfusion, has not brought significant clinical benefits to patients. Methods: . Results: gene. Discussion: axis identified in this study may serve as a novel target to improve therapeutic intervention of NK cells in tumor immunotherapy.