PBK-Loaded secretory autophagosomes drive radiotherapy-induced systemic adipose depletion via MAPK/ERK-PRKA/PKA-LIPE/HSL signaling: a therapeutic target for esophageal cancer cachexia
ADSCs: adipose-derived stem cells; CM: conditioned media; ESCC: esophageal squamous cell carcinoma; EVs: extracellular vesicles; eWAT: epididymal white adipose tissue; GA: gastrocnemius muscle; iWAT: inguinal white adipose tissue; LIPE/HSL: lipase E, hormone sensitive type; LIR: LC3-interacting region; MAP2K1/MEK1: mitogen-activated protein kinase kinase 1; MAPK/ERK: mitogen-activated protein kinase; OS: overall survival; PBK: PDZ binding kinase; PRKA/PKA: protein kinase cAMP-dependent; RT: radiotherapy; SAPs: secretory autophagosomes; sEVs: small extracellular vesicles.
Authors
- A Lian Chen
- Hongjiao Wang (ORCID: https://orcid.org/0000-0003-1221-5482)
- Jianbo Wang (ORCID: https://orcid.org/0000-0003-4879-974X)
- Xin Chen (ORCID: https://orcid.org/0000-0003-2315-083X)
- Zhikai Li
- Yibin Jia
- Tingting Yang
- Guoyu Li
- Zhuo Li
Institutions
- Allen Institute for Brain Science (US)
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
- Yuxian People's Hospital (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1080/15548627.2026.2661313
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Shandong Province
- National Natural Science Foundation of China