Systematic review on effectiveness of flavonoids against breast cancer: insights from in-vitro, in-vivo studies and molecular pathway studies

OBJECTIVE: On a global scale, breast cancer is the most prevalent form of cancer that affects women and the leading cause of death. Radiation therapy, chemotherapy, and hormone therapy are the contemporary approaches that are utilized in the treatment of breast cancer. However, these treatments come with a number of downsides, including resistance to medicine, unpleasant side effects, and treatment outcomes that are not satisfying enough to be considered satisfactory. The most important objective of this review was to incorporate the most recent discoveries about flavonoids, which are a category of polyphenolic chemicals that are obtained from plants. The majority of flavonoids can be found in foods, including fruits, vegetables, and plants used for medicinal purposes. A number of studies have shown that flavonoids possess anticancer properties and hence could serve as adjunctive drugs for the treatment of BC. SIGNIFICANCE OF REVIEW: and molecular analyses of apoptosis induction, tumor volume reduction, angiogenesis inhibition, metastasis suppression, drug resistance reversal and breast cancer signaling pathway modulation. KEY FINDINGS: , and clinical evidence remains limited. Nanoparticles, nanoemulsions and micelles have recently emerged as new drug delivery systems that have been employed for formulation of poorly soluble drugs with the objective of increasing drug exposure. The information related to these new drug delivery systems is still mostly based on preclinical data. CONCLUSIONS: research have demonstrated that flavonoids have the potential to inhibit the growth of breast cancer cells during the treatment process. Nonetheless, their therapeutic significance remains ambiguous due to constraints associated with pharmacokinetics, attainable exposure levels, and dosage practicality. Additional rigorously planned pharmacokinetic and clinical studies are necessary to ascertain their translational potential.