NF-κB signaling drives rapid skeletal muscle atrophy in patients with breast cancer: the cost of fighting cancer with chemotherapy
By combining acute and chronic muscle biopsies from patients with breast cancer with complementary in vitro experiments, we determined that breast cancer chemotherapy triggers a rapid skeletal muscle atrophy driven by NF-κB activation and subsequent upregulation of the ubiquitin-proteasome system. Importantly, sulfasalazine fully prevented muscle atrophy by mitigating the imbalance in protein turnover, offering promising perspectives for clinical translation and improving patient prognosis.
Authors
- Fabien Moinard‐Butot (ORCID: https://orcid.org/0000-0002-5630-5220)
- L. Debrut (ORCID: https://orcid.org/0000-0003-1534-8088)
- Joris Mallard (ORCID: https://orcid.org/0009-0009-0890-3136)
- Allan F. Pagano (ORCID: https://orcid.org/0000-0003-0717-2377)
- Roland Schött (ORCID: https://orcid.org/0000-0002-7735-5366)
- Fabrice Favret (ORCID: https://orcid.org/0000-0002-2827-9758)
- Thomas J. Hureau (ORCID: https://orcid.org/0000-0002-6993-5723)
- Anouk Charlot (ORCID: https://orcid.org/0000-0002-4731-3106)
- Céline Keime (ORCID: https://orcid.org/0000-0001-7604-3814)
- Elyse Hucteau (ORCID: https://orcid.org/0000-0002-9236-6514)
- Pierre Coliat (ORCID: https://orcid.org/0000-0003-3727-7508)
- X Pivot
- Abdelmalek Bendjama
- Lauréline Boutonnet
- Laura Somme
- Hervé Bischoff
- Léo Weltzer
- Alexandre Sharifi Tafreshi
- Claudie Billand
- Gilles LAVERNY (ORCID: https://orcid.org/0000-0002-2666-6877)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Levi Strauss (United States) (US)
- Université de Strasbourg (FR)
Publication Details
- Journal
- American Journal of Physiology-Cell Physiology
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1152/ajpcell.00148.2026
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00