Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors
> 500 µm). VTP-32 treatment (20 mg/kg) could effectively reduce viral load, alleviate clinical symptoms, and improve survival in EV-A71-infected mouse models. Mechanistic studies revealed that VTP-32 stabilizes 3A protein into an abnormal dimer, promotes viral siRNA generation, and ultimately leads to RNAi-mediated viral genome degradation. Overall, this study provides a promising countermeasure against enteroviral diseases and a rational design strategy for developing antiviral molecular glues.
Authors
- Xiong Xie
- Zezhong Liu (ORCID: https://orcid.org/0000-0002-7394-8084)
- Jinlin Wang (ORCID: https://orcid.org/0000-0003-4625-7605)
- Huoyan Tong
- Yukun Ren (ORCID: https://orcid.org/0000-0002-0167-1274)
- A X Wang
- Huidi Fan
- Jian Li
- Jianan Li
- Xi Zhou
- Hong Liu
- Wenhao Dai (ORCID: https://orcid.org/0000-0001-8508-7130)
- Botao Wu
Institutions
- Wuhan Institute of Virology (CN)
- Shanghai Institute of Materia Medica (CN)
- Ministry of Education (KR)
- Institute for Advanced Study (DE)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1002/advs.75317
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China