Single-cell transcriptomics reveal altered B cell responses and T cell senescence in geriatric non-responders to COVID-19 mRNA vaccination
), suggesting dysregulated B cell differentiation. Our findings point to impaired lymphocyte responses and increased immunosenescence in NR, emphasizing the need for enhanced vaccine strategies in aging populations.
Authors
- Debbie Keresztesy
- Leah L. Zagore
- Banumathi Tamilselvan (ORCID: https://orcid.org/0000-0003-3164-5162)
- Jeeda Ismail
- Htin Aung (ORCID: https://orcid.org/0000-0002-0465-6256)
- Mark J. Cameron (ORCID: https://orcid.org/0000-0003-4768-4094)
- Alejandro B. Balazs (ORCID: https://orcid.org/0000-0002-1767-3944)
- Oladayo A. Oyebanji (ORCID: https://orcid.org/0000-0001-5028-7474)
- David H. Canaday (ORCID: https://orcid.org/0000-0001-5503-7888)
- Cheryl M. Cameron
- Maegan Sheehan
- Brigid M. Wilson
- Stefan Gravenstein
- Michael Rubsamen
- Lenore Carias
- Kerri St. Denis
- Brian Richardson
- Michael Payne
- Christopher L. King
- Dennis Wilk
- Jillian Petrosky
Institutions
- Brown University (US)
- Ragon Institute of MGH, MIT and Harvard (US)
- Providence VA Medical Center (US)
- Louis Stokes Cleveland VA Medical Center (US)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- iScience
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1016/j.isci.2026.115730
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00