Hybrid channels containing the dupα7 subunit mediate resistance to α7-nAChR targeting therapy in metastatic melanoma
Metastatic melanoma is aggressive skin tumor often resistant to standard therapies. High α7-nAChR expression negatively correlates with survival of patients with metastatic melanoma, who are characterized by SLURP-1 drop in the plasma. Targeting α7-nAChR with recombinant SLURP-1 could significantly suppress metastatic melanoma cell migration; however, overexpression of human-specific dupα7 subunit forming hybrid α7/dupα7-nAChRs causes melanoma resistance to SLURP-1. This resistance can be overcome by the SLURP-1 mimicking peptide Oncotag, which exhibits activity against hybrid α7/dupα7-nAChRs.
Authors
- Mikhail A. Shulepko (ORCID: https://orcid.org/0000-0002-0436-2127)
- О. С. Бурова (ORCID: https://orcid.org/0000-0001-8897-0172)
- Hongshuang Wang (ORCID: https://orcid.org/0009-0001-8797-4822)
- Ekaterina N. Lyukmanova (ORCID: https://orcid.org/0000-0002-9728-9407)
- Maxim L. Bychkov (ORCID: https://orcid.org/0000-0001-8504-5256)
- Konstantin S. Yashin (ORCID: https://orcid.org/0000-0002-5723-7389)
- Philipp S. Orekhov (ORCID: https://orcid.org/0000-0003-4078-4762)
- Alexander S. Paramonov (ORCID: https://orcid.org/0000-0003-3614-560X)
- Igor Medyanik (ORCID: https://orcid.org/0000-0002-7519-0959)
- М. П. Кирпичников (ORCID: https://orcid.org/0000-0001-8170-1607)
- Artem V. Kirichenko (ORCID: https://orcid.org/0000-0001-8679-8604)
- Olga V. Shlepova (ORCID: https://orcid.org/0000-0001-8447-6417)
- Захар О. Шенкарев (ORCID: https://orcid.org/0000-0003-1383-3522)
- Irina N. Mikhaylova
- Dmitry S. Kulbatskii
- Xiaohui Wang
- Tamara Ya. Gornostaeva
Institutions
- Privolzhsky Research Medical University (RU)
- Russian Academy of Sciences (RU)
- Chinese Academy of Sciences (CN)
- Lomonosov Moscow State University (RU)
- Krasnoyarsk State Medical University (RU)
- Ministry of Health of the Russian Federation (RU)
- Moscow State University (TJ)
- Shenzhen Technology University (CN)
- Shenzhen MSU-BIT University
Publication Details
- Journal
- American Journal of Physiology-Cell Physiology
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1152/ajpcell.00730.2025
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00