Therapeutic potential of mesenchymal stem cells-derived exosomes loaded with elemental or nano selenium on diabetic nephropathy
levels coupled with increased GSH, SOD, CAT, and GPX, besides their anti-inflammatory and antiapoptotic effects, indicated by the decreased renal levels of IL-6, TGF-β, TNF-α, BAX, caspase-3, and P53, with Bcl-2 upregulation. Consequently, the kidney architecture in all diabetic-treated groups was greatly improved. Likely, the EX-loaded NSe treatment protocol highlighted the DN improvement superiority over the other two treatments.
Authors
- Ibrahim Youssef (ORCID: https://orcid.org/0000-0003-2228-0368)
- Dlovan Y. Khalil
- Mohamed Gaber Shalan (ORCID: https://orcid.org/0000-0003-1671-7172)
- Ehab I. El‐Hallous (ORCID: https://orcid.org/0000-0003-0189-3720)
- Dalal Sulaiman Alshaya (ORCID: https://orcid.org/0000-0002-0682-8189)
- Hanan M. Rashwan (ORCID: https://orcid.org/0000-0002-1550-0230)
- Fatema Suliman Alatawi (ORCID: https://orcid.org/0000-0002-3595-7828)
- Soha Y. Alkhaldi (ORCID: https://orcid.org/0009-0007-3648-8588)
- Shady G. El‐Sawah
- Lashin S. Ali
- Maha Ali Alghamdi
- Eman Fayad
- Nermine Beshara
- Tamer M. Shawky
- Khalid Elfaki Ibrahim
- Kholoud H. Radwan
- Esmael M. Alyami
Institutions
- Al-Ahliyya Amman University (JO)
- Princess Nourah bint Abdulrahman University (SA)
- St. George's University (GD)
- Cairo University (EG)
- Mansoura University (EG)
- Taif University (SA)
- King Saud University (SA)
- Southwestern Medical Center (US)
- Vision Medicals (China) (CN)
- Arish University (EG)
- Applied Visions (United States) (US)
- University of Sulaimani (IQ)
- Egyptian Russian University (EG)
- University of Tabuk (SA)
- King Khalid University (SA)
- Alexandria University (EG)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of drug targeting
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1080/1061186x.2026.2660824
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00