Recent advances in the design and development of small molecules against Lpx enzymes for mitigating <i>Pseudomonas aeruginosa</i> infections

techniques and synthetic procedures have been employed to develop inhibitors targeting a specific enzyme. The presence of the UDP-GlcNAc group, acyl chain-binding group, five-membered ring, amide group, benzamide group, heteroatom, and fused rings is a key set of features that provides a basic scaffold for designing Lpx inhibitors. The structural characteristics of the receptor responsible for prominent ligand interactions have also been discussed, providing a foundation for the development of selective and potent inhibitors.