Preclinical and First-in-Human Study of Carbonic Anhydrase IX–Targeting Theranostic Pair, [ <sup>68</sup> Ga]Ga/[ <sup>177</sup> Lu]Lu-NYM096, in Clear Cell Renal Cell Carcinoma
Lu]Lu-NYM096 is feasible, offering a strategy for patients with end-stage ccRCC. The gastric toxicity proposes a significant challenge for CAIX-targeting radiopharmaceutical therapy.
Authors
- Meixi Liu (ORCID: https://orcid.org/0000-0002-8146-4530)
- Yuejuan Cheng (ORCID: https://orcid.org/0000-0003-4491-2370)
- Xinchun Yan
- Chunmei Bai
- Yushi Zhang
- Wenjia Zhu
- Li Huo
- Xiaoyuan Li (ORCID: https://orcid.org/0000-0003-1618-5794)
- Xueqian Yang
- Jingnan Wang
- Guoyang Zheng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Journal of Nuclear Medicine
- Published
- 2026-04-16
- DOI
- https://doi.org/10.2967/jnumed.125.271604
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00