Impacts of stent characteristics on periprocedural ischemic events in elective PCI: the ALPHEUS-stents study
BACKGROUND: Stents characteristics can have a tremendous impact on the incidence of periprocedural ischemic events following percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS). The ALPHEUS-stents study aimed to describe the association between stents lengths and characteristics on the occurrence of periprocedural ischemic events. METHODS: The study included patients with CCS undergoing elective PCI with at least one high-risk feature. The primary endpoint of the study was the composite of type 4a/4b myocardial infarction (MI) and periprocedural major myocardial injury evaluated at 48 h or discharge. First, we evaluated the association between total stent length and primary outcome using a multivariate logistic regression considering stent length as a continuous variable and adjusting for relevant covariates. Then we evaluated the associations between stent diameter, strut thickness, platform composition, polymer type, coating distribution and eluted drugs with the primary endpoint using a multivariable logistic regression model, with stent length categorized within the aforementioned subgroups. RESULTS: The primary endpoint occurred in 639 patients (35.8%). After adjustment, total stent length was significantly associated with the primary endpoint (adjusted Odds Ratio (aOR) 1.028 95%CI [1.028-1.029] per millimeter). No significant associations were observed across categories of stent diameter, strut thickness, platform composition or coating distribution. However, biolimus-eluting stents (aOR 1.051 [1.035-1.067], p = 0.006 vs other eluted drugs) were independently associated with an increased risk of the primary outcome. CONCLUSIONS: In patients undergoing elective PCI, the risk of periprocedural ischemic events is adequately captured by the total stent length. Biolimus-eluted stents might confer a higher risk of periprocedural ischemic events. CLINICALTRIALS: gov number: NCT02617290.
Authors
- Paul Guedeney (ORCID: https://orcid.org/0000-0002-2012-4137)
- Arnaud Ferrante (ORCID: https://orcid.org/0000-0002-5949-0855)
- Grégoire Rangé (ORCID: https://orcid.org/0000-0001-7073-354X)
- R. Dumaine
- Jean-Jacques Portal (ORCID: https://orcid.org/0000-0002-3694-456X)
- Ghilas Rahoual
- Stéphanie Rouanet (ORCID: https://orcid.org/0009-0003-5812-3599)
- Michel Zeitouni (ORCID: https://orcid.org/0000-0001-9562-3128)
- Zuzana Moťovská (ORCID: https://orcid.org/0000-0002-5319-473X)
- Mohamad El Kasty (ORCID: https://orcid.org/0000-0002-7571-9349)
- Mathieu Kernéis (ORCID: https://orcid.org/0000-0002-7141-5209)
- Niki Procopi (ORCID: https://orcid.org/0000-0001-7700-0744)
- Louis Giovachini (ORCID: https://orcid.org/0009-0003-3562-813X)
- Guillaume Cayla
- Olivier Barthelemy
- Farzin Beygui
- Johanne Silvain
- Eric Vicaut
- Grégory Ducrocq
- Gilles Montalescot
- Mikael Laredo
Institutions
- Inserm (FR)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Charles University (CZ)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Réadaptation Cardiaque Les Grands Prés (FR)
- Hôpital Fernand-Widal (FR)
- Les Hôpitaux de Chartres (FR)
- Pitié-Salpêtrière Hospital (FR)
- Société Française de Cardiologie (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Unité de recherche sur les maladies cardiovasculaires et métaboliques (FR)
- University Hospital Kralovske Vinohrady (CZ)
- Université Paris 1 Panthéon-Sorbonne (FR)
- Université de Nîmes (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- International Journal of Cardiology
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1016/j.ijcard.2026.134506
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00