Translation and validation of the Migraine Interictal Burden Scale (MIBS-4) in an Italian clinical cohort

The Migraine Interictal Burden Scale (MIBS-4) is a brief validated patient-reported measure of migraine interictal impact; however, an official Italian translation is not currently available. The MIBS-4 was translated and culturally adapted into Italian language and psychometrically evaluated in adults with episodic or chronic migraine enrolled in the Italian Headache Registry (RICe). In a 4-week test–retest design, participants completed the Italian version of MIBS-4 and the Migraine Disability Assessment (MIDAS) at baseline (T0) and at follow up (T1). We assessed internal consistency, dimensionality, test–retest reliability, convergent validity, and known-groups validity across MIDAS disability grades. A total of 191 patients with migraine were included in test–retest analyses. Internal consistency was good to excellent (Cronbach’s α = 0.86 at T0; 0.90 at T1; ordinal α = 0.91–0.94; McDonald’s ω = 0.88–0.91). Parallel analysis supported a stable one-factor solution at both timepoints. Item-level agreement was moderate (weighted κ = 0.45–0.60; all p < 0.001), as was the total-score stability (ICC[A,1] = 0.62, 95% CI 0.50–0.72). Convergent validity with MIDAS was moderate (ρ = 0.40 at T0; ρ = 0.33 at T1; both p < 0.001). The present findings indicate that the Italian MIBS-4 is psychometrically robust and captures a dimension of migraine burden that is only partially explained by conventional attack-focused disability measures. The Italian version of MIBS-4 provides a reliable instrument for quantifying interictal burden in Italian-speaking migraine individuals, enabling a more comprehensive evaluation of migraine and supporting individualized management.

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Journal
Neurological Sciences
Published
2026-04-17
DOI
https://doi.org/10.1007/s10072-026-09029-w
Primary Topic
Migraine and Headache Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Translation and validation of the Migraine Interictal Burden Scale (MIBS-4) in an Italian clinical cohort

Milena Zucca, Diego Centonze, Grazia Sances, Maria Albanese et al.
Neurological Sciences
Migraine and Headache Studies
article

Translation and validation of the Migraine Interictal Burden Scale (MIBS-4) in an Italian clinical cohort

Milena Zucca, Diego Centonze, Grazia Sances, Maria Albanese, Antonio Taglialatela, Edoardo Mampreso, Fausto Roveta, Gennaro Saporito, Alberto Chiarugi, Yan Tereshko, Vittoria Carla D’Agostino, Elisa Maria Piella, Giada Giuliani, Michele Corrado, Chiara Zilli, Damiano Paolicelli, Roberto De Icco, Martino Gentile, Raffaele Ornello, Antonio Munafò, Federico De Santis, Stefania Battistini, Francesca Boscain, Innocenzo Rainero, Danilo Antonio Montisano, Maria Pia Prudenzano, Enrica Maria Puddu, Renata Rao, Marcello Silvestro, Alberto Mario Chiarandon, Antonio Russo, Marta Altieri, Francesca Pistoia, Elisa Rubino, Simona Sacco, Cristina Tassorelli, on behalf of the Italian Headache Registry (RICe) Study Group, Mariarosaria Valente, Licia Grazzi, Fabio Ferrandes, Gloria Vaghi
article en

Abstract

The Migraine Interictal Burden Scale (MIBS-4) is a brief validated patient-reported measure of migraine interictal impact; however, an official Italian translation is not currently available. The MIBS-4 was translated and culturally adapted into Italian language and psychometrically evaluated in adults with episodic or chronic migraine enrolled in the Italian Headache Registry (RICe). In a 4-week test–retest design, participants completed the Italian version of MIBS-4 and the Migraine Disability Assessment (MIDAS) at baseline (T0) and at follow up (T1). We assessed internal consistency, dimensionality, test–retest reliability, convergent validity, and known-groups validity across MIDAS disability grades. A total of 191 patients with migraine were included in test–retest analyses. Internal consistency was good to excellent (Cronbach’s α = 0.86 at T0; 0.90 at T1; ordinal α = 0.91–0.94; McDonald’s ω = 0.88–0.91). Parallel analysis supported a stable one-factor solution at both timepoints. Item-level agreement was moderate (weighted κ = 0.45–0.60; all p < 0.001), as was the total-score stability (ICC[A,1] = 0.62, 95% CI 0.50–0.72). Convergent validity with MIDAS was moderate (ρ = 0.40 at T0; ρ = 0.33 at T1; both p < 0.001). The present findings indicate that the Italian MIBS-4 is psychometrically robust and captures a dimension of migraine burden that is only partially explained by conventional attack-focused disability measures. The Italian version of MIBS-4 provides a reliable instrument for quantifying interictal burden in Italian-speaking migraine individuals, enabling a more comprehensive evaluation of migraine and supporting individualized management.

Neurological SciencesVol. 47(5)
University of Siena (IT), University of Rome Tor Vergata (IT), University of Udine (IT), University of Padua (IT), University of Campania "Luigi Vanvitelli" (IT), University of Pavia (IT), University of L'Aquila (IT), Istituto Neurologico Mediterraneo (IT), Fondazione Istituto Neurologico Nazionale Casimiro Mondino (IT), San Salvatore Hospital (IT), Azienda Ospedaliero-Universitaria Careggi (IT), Fondazione IRCCS Istituto Neurologico Carlo Besta (IT), University of Florence (IT), University of Turin (IT), University of Bari Aldo Moro (IT), University of Brescia (IT), Sapienza University of Rome (IT)
Dipartimenti di Eccellenza, Università degli Studi di Torino
Openalex Percentile: Top 18%
Migraine and Headache Studies
DOIOpen Access PDFOpenAlex
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