Revisiting the antizyme 1 – ODC interaction reveals low-nanomolar affinity
1-4 nM in solution), affinity substantially stronger than previous estimates in the 200-700 nM range. Our results provide new insight into the functioning of the ODC regulatory network, which affects the downstream polyamine synthesis pathway. Such sensitive tools are needed for screening compound libraries and characterizing promising candidates that could affect ODC activity and consequently, polyamine levels.
Authors
- Tomasz Kantyka (ORCID: https://orcid.org/0000-0003-3023-2382)
- Paweł Kochanowski (ORCID: https://orcid.org/0000-0001-7115-2405)
- Grzegorz Bereta (ORCID: https://orcid.org/0000-0002-2925-7796)
- Elżbieta Wątor-Wilk
- Jakub Nowak
- Przemysław Grudnik
Institutions
- Jagiellonian University (PL)
- Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences (PL)
Publication Details
- Journal
- Amino Acids
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1007/s00726-026-03519-z
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundacja na rzecz Nauki Polskiej