Managing Breakthrough Fungal Infections in Hematologic Patients: Determinants and Practical Management from a Latin American Perspective on Behalf of INFOCUS LATAM–ISHAM Working Group
spp. Early clinical recognition, rapid therapy escalation, aggressive diagnostic investigation, a switch to liposomal amphotericin B-based regimens in patients on azole prophylaxis, and therapeutic drug monitoring are essential to improve outcomes. Reducing the growing global burden of bIFIs will also require improved access to high-quality diagnostics and strengthened educational and stewardship efforts that prioritize antifungal resistance as an urgent health concern.
Authors
- Márcio Nucci (ORCID: https://orcid.org/0000-0003-4867-0014)
- Daniel Aguilar-Zapata (ORCID: https://orcid.org/0000-0001-7482-1301)
- Pablo Andrés Moncada (ORCID: https://orcid.org/0000-0001-9170-3016)
- Arnaldo Lopes Colombo (ORCID: https://orcid.org/0000-0003-0793-8491)
- Giovanni Luís Breda (ORCID: https://orcid.org/0000-0001-7092-8830)
- Ricardo Rabagliati (ORCID: https://orcid.org/0000-0002-0574-8312)
- Larissa Simão Gandolpho
- Fernando Riera (ORCID: https://orcid.org/0000-0002-0618-1899)
- Mariana Guaraná (ORCID: https://orcid.org/0000-0003-0077-4121)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Pontificia Universidad Católica de Chile (CL)
- Universidad Nacional de Córdoba (AR)
- Hospital General de México (MX)
- Universidade Nove de Julho (BR)
- Instituto de Salud Pública de Chile (CL)
- Hospital Universitário Gaffrée e Guinle (BR)
- Fundación Valle del Lili (CO)
- Centro Científico Tecnológico - Córdoba (AR)
- CNR de la Résistance aux Antibiotiques (FR)
- Hospital de Clínicas Universidade Federal do Paraná (BR)
- Sociedade Brasileira de Oncologia Clínica (BR)
- Fundacion Allende (AR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Microorganisms
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/microorganisms14040904
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo