Establishment and validation of a risk scoring model for predicting the risk of bladder stones in patients with benign prostatic hyperplasia
Purpose: The aim of this study is to identify independent risk factors for bladder stones in patients with benign prostatic hyperplasia (BPH), and to develop and validate a nomogram prediction model for assessing the risk of bladder stones in this patient population. Methods: Retrospective analysis included 446 BPH patients (106 with bladder stones, 340 without) who underwent transurethral resection of the prostate (2023-2025). Univariate ROC (receiver operating characteristic), correlation analysis, LASSO regression, and multivariate logistic regression were used for variable screening and model construction. The cohort was split into training (70%) and validation (30%) sets. Model performance was evaluated via AUC (discrimination), calibration curves, Hosmer-Lemeshow test (calibration), and DCA (clinical utility). Results: > 0.05), and robust clinical utility. Conclusion: The nomogram overcomes univariate and multicollinearity limitations, enabling precise individualized risk assessment of bladder stones in BPH patients. It serves as a reliable tool for clinicians to guide personalized monitoring and prevention, potentially reducing incidence and healthcare burdens.
Authors
- Hongzhi Fang (ORCID: https://orcid.org/0000-0002-1270-756X)
- Yi Luo (ORCID: https://orcid.org/0000-0003-0007-0394)
- Yi Gao
- Changjian Shi
- Yunfei Li
- Jie Xu
- Xinyi Li
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3389/fmed.2026.1795565
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province