Autopolyploidization reshapes transcription factor regulatory networks and enhances MAPK-associated thermotolerance in rice

) forming a coordinated regulatory core. These findings suggest that autopolyploidization enhances thermotolerance by restructuring TF-centered regulatory networks, reinforcing MAPK-hormone signaling integration, and strengthening recovery-phase transcriptional reprogramming. Our study provides network-level insights into how genome duplication promotes stress resilience in rice.