[3-<sup>11</sup>C]Pyruvate PET detects alterations in cardiac pyruvate metabolism induced by doxorubicin chemotherapy.
C]Pyruvate PET is therefore a promising approach to imaging cardiac pyruvate transport with potential applications to the identification of early maladaptive changes in pyruvate metabolism and monitoring response to therapy.
Authors
- John W. Babich (ORCID: https://orcid.org/0000-0002-1616-3416)
- Kayvan R. Keshari (ORCID: https://orcid.org/0000-0002-5181-8035)
- Sadek A. Nehmeh (ORCID: https://orcid.org/0000-0002-3129-5003)
- Thomas Ruan
- Shuvra Debnath (ORCID: https://orcid.org/0000-0002-7290-2957)
- James Marshall Kelly (ORCID: https://orcid.org/0000-0002-0525-0047)
- Chulhee Lee (ORCID: https://orcid.org/0000-0002-7769-9556)
- Anja Wacker
- G. F. Figlioli
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Citigroup (US)
- Cornell University (US)
- RaNA Therapeutics (United States) (US)
- Molecular Innovations (United States) (US)
- Imaging Center (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- PubMed
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1038/s44303-026-00165-8
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00