Preoperative (Neoadjuvant) Combined Chemoradiotherapy in the Management of Localized Soft Tissue Sarcoma: A Retrospective Study
Our institutional protocol utilizing two cycles of MitoAP with RT was well tolerated. DSS in our cohort was similar to historical data using perioperative RT alone, suggesting no clear benefit from CCRT. However, the majority of patients in our cohort were classified as high risk, which may have attenuated a potential survival benefit in the absence of appropriate comparative controls. Furthermore, additional perioperative CT to CCRT was associated with improved DSS and differential histology-specific responses in tumor viability, suggesting that a more aggressive neoadjuvant and perioperative approach may be beneficial in selected patients.
Authors
- Steven Ian Robinson (ORCID: https://orcid.org/0000-0002-1648-1908)
- Scott H. Okuno (ORCID: https://orcid.org/0000-0002-1297-6946)
- Safia K. Ahmed (ORCID: https://orcid.org/0000-0003-2482-594X)
- Matthew T. Houdek (ORCID: https://orcid.org/0000-0003-0390-1018)
- Brittany L. Siontis (ORCID: https://orcid.org/0000-0002-9471-6792)
- Travis E. Grotz (ORCID: https://orcid.org/0000-0002-7753-097X)
- Judith Jebastin Thangaiah
- Andrew L. Folpe (ORCID: https://orcid.org/0000-0002-0273-7351)
- Georgios M. Stergiopoulos (ORCID: https://orcid.org/0009-0009-7315-248X)
- Thanh P. Ho (ORCID: https://orcid.org/0000-0001-7659-5766)
Institutions
- Mayo Clinic (US)
- Georgetown University (US)
- Georgetown University Medical Center (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
Publication Details
- Journal
- Cancers
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/cancers18081260
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00