Cervicovaginal dysbiosis and microenvironment disruption are associated with cervical carcinogenesis
and the increase in anaerobes, is crucial in promoting the malignant progression of cervical lesions. As cervical carcinogenesis progresses, the relative abundance of anaerobes increases in the deteriorating vaginal microenvironment. We systematically analyzed the relationship between CVM and the vaginal microenvironment in cervical lesions, aiming to reveal the contribution of CVM with specific vaginal microenvironmental features and its functional changes in the progression of cervical carcinogenesis. Our results may provide new insights into the etiology and pathogenesis of cervical cancer from the perspective of vaginal microecology.
Authors
- M. Zhang
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Li Song (ORCID: https://orcid.org/0000-0003-1415-584X)
- Kailu Zhao
- Meng Cui (ORCID: https://orcid.org/0000-0002-4426-2489)
- Yuanjing Lyu (ORCID: https://orcid.org/0000-0003-0936-8306)
- Jianjun Zhang
- Rui Mao
- Ling Ding
- Zhilian Wang
Institutions
- Boston University (US)
- Shanxi Medical University (CN)
- Quest University Canada (CA)
- Fudan University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Taiwan Centers for Disease Control (TW)
- Richard M. Fairbanks Foundation (US)
- Inner Mongolia Medical University (CN)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1128/spectrum.02804-24
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China