The relationship between obesity and disease relapse in systemic lupus erythematosus: a retrospective cohort study using the LUNA registry
Objectives: Recent reports have suggested an association between the pathogenesis of systemic lupus erythematosus (SLE) and various adipokines secreted by adipocytes. However, the impact of obesity on the susceptibility to SLE relapses remains unclear. This study investigated the association between obesity and relapse in patients with SLE using a large, multicenter cohort. Methods: ) groups. Results: = 0.01). Conclusion: Patients with mild obesity had lower relapse rates than those with normal BMI. The findings suggest that metabolic status may influence the disease course of SLE. Appropriate weight management guidance, including avoiding excessive dietary restriction, may help prevent SLE relapses.
Authors
- Daiga Kishimoto (ORCID: https://orcid.org/0000-0001-9947-7009)
- Masao Katsushima (ORCID: https://orcid.org/0009-0007-0033-1757)
- Yasuhiro Shimojima (ORCID: https://orcid.org/0000-0001-7100-1121)
- Hirofumi Miyake (ORCID: https://orcid.org/0000-0001-5655-6356)
- Hiroki Mizuno (ORCID: https://orcid.org/0000-0003-4187-1067)
- Yoshia Miyawaki (ORCID: https://orcid.org/0000-0002-6981-3443)
- Chiharu Hidekawa (ORCID: https://orcid.org/0009-0007-4837-5038)
- Yuji Yoshioka (ORCID: https://orcid.org/0000-0002-3361-3757)
- Tomoaki Ida (ORCID: https://orcid.org/0000-0002-8023-336X)
- Shigeru Ohno
- Hiroto Nakano
- Takahisa Onishi
- Natsuki Sakurai
- Yusuke Matsuo
- Keisuke Nishimura
- Ken-ei Sada
- Kei Ikeda
- Ryusuke Yoshimi
- Kaoru Takase-Minegishi
- Ayuko Takatani
- Hiroshi Kajiyama
- Akira Onishi
- Michio Fujiwara
- Takashi Kida
- Kunihiro Ichinose
- Toshimasa Shimizu
- Hideaki Nakajima
- Naoki Suzuki
- Nobuyuki Yajima
- Kunihiko Umekita
- Shuzo Sato
Institutions
- University of Miyazaki (JP)
- SHOWA Medical University (JP)
- Fukushima Medical University (JP)
- Shinshu University (JP)
- Okayama University (JP)
- Shimane University (JP)
- Kyoto University (JP)
- Yokohama City University Medical Center (JP)
- Tenri Hospital (JP)
- Kyoto Prefectural University of Medicine (JP)
- Yokohama Minami Kyosai Hospital (JP)
- Sasebo City General Hospital (JP)
- Yokohama City University Hospital (JP)
- Chiba University Hospital (JP)
- Institute for Rheumatic Diseases (Japan) (JP)
- Kure Kyosai Hospital (JP)
- Yokohama Rosai Hospital (JP)
- Universidad Metropolitana (VE)
- Kagawa Prefectural Central Hospital (JP)
- Nagasaki University (JP)
- Osaka Metropolitan University (JP)
- Kobe University (JP)
- Kōchi University (JP)
- Dokkyo Medical University (JP)
- Saitama Medical University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3389/fimmu.2026.1781933
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science