Humoral Immunogenicity of SARS-CoV-2 mRNA Primary Vaccination Among People with HIV
= 0.04). Neutralizing titers correlated positively with CD4 counts among PWH. Responses were broadly comparable between PWH and HIV-negative controls and did not differ substantially by vaccine type. These findings indicate that immune status, reflected by CD4 T-cell count, is a key determinant of SARS-CoV-2 vaccine-induced humoral responses in PWH and support prioritizing vaccination strategies for individuals with advanced immunosuppression.
Authors
- Paula Suanzes (ORCID: https://orcid.org/0000-0002-6871-0098)
- Paloma Jiménez
- Beatriz Mothe (ORCID: https://orcid.org/0000-0001-9975-407X)
- Javier García‐Pérez (ORCID: https://orcid.org/0000-0001-7551-7803)
- María J. Buzón (ORCID: https://orcid.org/0000-0003-4427-9413)
- José María Miró (ORCID: https://orcid.org/0000-0001-8057-7755)
- Francisco Homar (ORCID: https://orcid.org/0000-0003-0116-3277)
- Susana Benet (ORCID: https://orcid.org/0000-0002-2219-8826)
- Andreu Bruguera (ORCID: https://orcid.org/0000-0002-7524-0768)
- Gemma Navarro (ORCID: https://orcid.org/0000-0002-7195-9046)
- Juliana Reyes- Urueña
- Sonsoles Sánchez-Palomino (ORCID: https://orcid.org/0000-0002-9142-812X)
- Daniel K. Nomah
- Mercedes Garcia-Gasalla
- The COVIHVAC Study Group
- Jordi Casabona
- Juan M. Tiraboschi (ORCID: https://orcid.org/0000-0002-0073-873X)
- Alba G. Robles
- Ingrid Vilaró (ORCID: https://orcid.org/0000-0003-1875-6618)
Institutions
- Real Academia Española (ES)
- Generalitat de Catalunya (ES)
- Instituto de Salud Carlos III (ES)
- Bellvitge University Hospital (ES)
- IrsiCaixa (ES)
- Hospital Son Llatzer (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Centro de Investigación Biomédica en Red (ES)
- Health Research Institute of the Balearic Islands (ES)
- Institute of Research and Innovation Parc Tauli (ES)
- Hospital Universitari de Vic (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Publication Details
- Journal
- Microorganisms
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/microorganisms14040893
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Instituto de Salud Carlos III
- Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona