Detrended fluctuation analysis of amygdala-hippocampal beta synchrony reveals network rigidity in depression associated with temporal lobe epilepsy
. Depressive symptoms in TLE are associated with more temporally persistent, less flexible beta band limbic network dynamics. These findings highlight the temporal organization of amygdala-hippocampal synchrony as a potential network-level signature of affective dysfunction within epilepsy and may inform future approaches to monitoring and modulating mood-related circuit activity in this population.
Authors
- Victoria M. Ho (ORCID: https://orcid.org/0000-0003-4159-1356)
- Kurt Y. Qing (ORCID: https://orcid.org/0000-0003-1283-2931)
- Beth A. Lopour (ORCID: https://orcid.org/0000-0003-4233-4802)
- Lilit Mnatsakanyan
- Sumeet Vadera
- D. A. Pizzagalli
- Mona Sazgar (ORCID: https://orcid.org/0000-0001-7406-0848)
- Sebastian Hanna
- Jack Lin
- Melanie Lucas (ORCID: https://orcid.org/0009-0000-0543-3153)
- Brian Chang Jung (ORCID: https://orcid.org/0000-0002-8967-2465)
- Doris Deng
- David King-Stephens
Institutions
- University of California, Los Angeles (US)
- University of California, Irvine (US)
- University of California, Irvine Medical Center (US)
- Irvine University (US)
- University of California Davis Medical Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Neural Engineering
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1088/1741-2552/ae60d0
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00