Sex-dependent myocardial necrosis-like signaling in rats with heart failure due to chronic pressure overload
This study identifies necroptosis as a key pathomechanism in pressure overload-induced heart failure, with sex-dependent, prodeath molecular events. Novel findings indicate distinct pronecroptotic triggers: in males, necroptosis is driven by oxidative stress and mitochondrial DNA damage, whereas in females, a proinflammatory pathway involving tumor necrosis factor and compensatory mitochondrial biogenesis predominates. Pyroptosis and ferroptosis do not appear to be prominent. These sex-specific molecular necrosis-like divergences are important for developing personalized therapeutic strategies for heart failure.
Authors
- Jaroslav Hrdlička
- Jan Neckář
- Csaba Horváth (ORCID: https://orcid.org/0000-0003-2624-0072)
- Izabela Jarabicová (ORCID: https://orcid.org/0000-0002-0705-0938)
- Eva Nekvindová
- Veronika Olejníčková (ORCID: https://orcid.org/0000-0002-0991-1420)
- Adriana Adameová (ORCID: https://orcid.org/0000-0002-9803-043X)
- Andrea Marciníková
Institutions
- Czech Academy of Sciences (CZ)
- Slovak Academy of Sciences (SK)
- Charles University (CZ)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- American Journal of Physiology-Heart and Circulatory Physiology
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1152/ajpheart.00064.2026
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Grantová Agentura České Republiky
- Agentúra na Podporu Výskumu a Vývoja
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- Agentura Pro Zdravotnický Výzkum České Republiky
- Farmaceutická fakulta, Univerzita Komenského v Bratislave
- NextGenerationEU