Jejunal Mesenteric Well-Differentiated Liposarcoma With Isolated Omental Metastases: Evidence of Focal Dedifferentiation

A malignant tumor of adipocytic origin, liposarcoma typically affects the deep soft tissues and retroperitoneum. Although primary mesenteric liposarcoma is uncommon, its association with isolated omental metastasis is a rare entity. A 65-year-old male presented with a painless, progressively enlarging abdominal mass. Imaging revealed multiple fat-attenuated intra-abdominal lesions. Surgical exploration confirmed a large lobulated mesenteric mass and an omental mass. Wide local excision with omentectomy and jejuno-jejunal anastomosis was performed. Histopathology confirmed well-differentiated liposarcoma with focal areas of dedifferentiation with omental metastasis. The patient had an uneventful postoperative recovery and was referred for adjuvant therapy. Jejunal mesenteric liposarcoma with omental metastasis is a rare entity. Prompt diagnosis and complete surgical resection with negative margins are the mainstay of management. Long-term surveillance is required due to recurrence risk.