Anti-Aging Effects of Vaccinium bracteatum Thunb. Leaves Extracts via Activation of the Nrf2 Antioxidant Pathway
signaling pathway. Mechanistically, xanthotoxol activated the Nrf2 signaling pathway, promoting the expression of its downstream targets heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1). This study demonstrates that VBTL and its active compound xanthotoxol exert anti-aging effects across multiple models by modulating the Nrf2 pathway, providing both theoretical and experimental foundations for developing VBTL as a novel, safe, and effective natural ingredient in anti-aging functional foods.
Authors
- L Liu
- Qing Hu
- Jianming Luo (ORCID: https://orcid.org/0000-0001-5389-6902)
- Xichun Peng (ORCID: https://orcid.org/0000-0002-4804-5203)
- Fenfa Li
- Caiyun Zhang (ORCID: https://orcid.org/0000-0002-9570-0207)
Institutions
- Jinan University (CN)
Publication Details
- Journal
- Foods
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/foods15081393
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jinan University