Exploring the Holdase Activity of Supramolecular Chaperones with Amyloid-Forming Peptides and Insulin
effectively eliminates insulin aggregation for multiple days in the presence of chemical and mechanical stressors. These findings expand both our understanding and the potential therapeutic relevance of amphiphilic dendrons as an emerging approach to tackle protein aggregation.
Authors
- Bradley L. Nilsson (ORCID: https://orcid.org/0000-0003-1193-3693)
- Benjamin E. Partridge (ORCID: https://orcid.org/0000-0003-2359-1280)
- Hannah E. Distaffen (ORCID: https://orcid.org/0000-0003-3570-2638)
- Todd D. Krauss (ORCID: https://orcid.org/0000-0002-4860-874X)
- Elizabeth R. Piedmont (ORCID: https://orcid.org/0000-0003-4135-7949)
- Lisbeth C. Crompton
Institutions
- Instituto de Óptica "Daza de Valdés" (ES)
- Division of Materials Science and Engineering (AU)
- University of Rochester (US)
Publication Details
- Journal
- Biomacromolecules
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1021/acs.biomac.5c02408
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NIH Office of the Director
- National Institute of General Medical Sciences
- Division of Chemistry