Absence of a dose–response relationship after intra-oropharyngeal inoculation of pigs with foot-and-mouth disease virus serotype O
using IOP inoculation. In all experiments, intradermal heel bulb (IDHB) inoculation served as a positive control. Overall, results of IOP were variable and strain-dependent, without a dose-response relationship, while IDHB reliably caused infection even at low doses. No single factor responsible for the observed variation was identified. These findings indicate that, unlike IDHB, the outcome of IOP inoculation does not consistently lead to infection with FMDV.
Authors
- A. Dekker (ORCID: https://orcid.org/0000-0002-0519-9587)
- Selma Schmidt
- Saskia Weber (ORCID: https://orcid.org/0000-0002-1492-7566)
- K. Wisnewski
- Ryan Waters
- Constantin Lorenz
- Wilhelm Gerner
- Phaedra Eblé
- Michael Eschbaumer
Institutions
- The Pirbright Institute (GB)
- Friedrich-Loeffler-Institut (DE)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Veterinary Research
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1186/s13567-026-01751-9
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- European Commission
- Pirbright Institute
- Directorate for Biological Sciences
- HORIZON EUROPE Framework Programme
- Biotechnology and Biological Sciences Research Council