Beyond Vaccination: Persistent Meningococcal Risk in Anti-C5–Treated aHUS—Case Report and Review of Literature
: This case highlights that breakthrough invasive infections may occur despite adherence to recommended preventive strategies. It underscores the need for sustained clinical vigilance, timely vaccine boosters, and careful reassessment of the risk-benefit balance of continued complement inhibition therapy.
Authors
- Andrea Moscatelli (ORCID: https://orcid.org/0000-0002-7839-317X)
- Elio Castagnola (ORCID: https://orcid.org/0000-0002-5336-8429)
- Enrico Verrina (ORCID: https://orcid.org/0000-0002-5178-1949)
- Marcello Mariani (ORCID: https://orcid.org/0000-0003-2989-7301)
- Micaela Gentile
- Simona Matarese
- Gabriele Mortari (ORCID: https://orcid.org/0009-0002-7113-6258)
- Edoardo La Porta (ORCID: https://orcid.org/0000-0003-2368-1139)
- Marta Romanengo (ORCID: https://orcid.org/0000-0002-1833-037X)
- Alessio Mesini (ORCID: https://orcid.org/0000-0003-0593-4112)
- Giacomo Brisca (ORCID: https://orcid.org/0000-0001-7992-0181)
- Gianluigi Ardissino
Institutions
- Istituto Giannina Gaslini (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Guglielmo da Saliceto Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Journal of Clinical Medicine
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/jcm15083048
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alexion Pharmaceuticals