The prognostic impact of prior atopic dermatitis on cutaneous T-cell lymphoma: a single-center retrospective cohort study

In a single-center retrospective cohort of 605 patients with cutaneous T-cell lymphoma (CTCL), a prior history of atopic dermatitis (AD) was independently associated with longer diagnostic delay, advanced-stage CTCL at presentation, increased disease progression, greater infectious and psychiatric comorbidity burden, and reduced overall survival. These associations were most pronounced among patients with severe AD requiring systemic therapy and were not modified by age at AD onset.