Targeting Apoptosis-Resistant Proliferation: Imatinib-Based Combinations Induce Durable Cytostatic Arrest in 3D Endometrial Cancer Spheroids
Imatinib-based combinations suppress 3D endometrial cancer growth predominantly through sustained cell cycle arrest rather than apoptosis induction. Targeting apoptosis-resistant proliferation through cytostatic mechanisms may represent a complementary therapeutic strategy for hormone-responsive endometrial cancer and warrants further translational evaluation.
Authors
- Burcu Biltekin (ORCID: https://orcid.org/0000-0002-8435-6797)
- Ayhan Bılır (ORCID: https://orcid.org/0009-0009-9399-5927)
- Berna Yıldırım (ORCID: https://orcid.org/0000-0002-4479-2586)
- Mete Hakan Karalök (ORCID: https://orcid.org/0000-0002-6814-6212)
Institutions
- Istanbul University (TR)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/biomedicines14040906
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00