Ketamine Use in Critically Ill Patients: Insights into Depressive Symptoms and Hemodynamic Changes
< .05). Hemodynamic parameters remained stable; heart rate increased transiently at 15-30 min post-infusion, returning to baseline by 60-90 min. Adverse effects observed were anxiety (12.5%), restlessness and/or agitation (10.4%), and dissociation (8.16%).ConclusionSubanesthetic ketamine improved specific depressive symptoms in critically ill ICU patients without significant hemodynamic instability. These findings support its potential as a rapid-acting antidepressant in the ICU, warranting further prospective trials.
Authors
- Abby Hanson (ORCID: https://orcid.org/0000-0003-3195-511X)
- Ivan Alfredo Huespe (ORCID: https://orcid.org/0000-0003-3445-6981)
- Michelle Ojard
- Devang K. Sanghavi (ORCID: https://orcid.org/0000-0003-4742-8963)
- Katie L. Kunze (ORCID: https://orcid.org/0000-0001-6850-6823)
- Pablo Moreno Franco (ORCID: https://orcid.org/0000-0001-9146-5599)
- Patrick W. Johnson (ORCID: https://orcid.org/0000-0001-8365-1375)
- Lekhya Raavi
- Shahin Isha (ORCID: https://orcid.org/0000-0002-6613-6395)
- Saurabh Ashok Sujanyal (ORCID: https://orcid.org/0000-0002-9109-9231)
- Michael A. Edwards (ORCID: https://orcid.org/0000-0003-4811-0789)
- Faiz Saleem
- Mohit Chauhan (ORCID: https://orcid.org/0000-0001-8848-4385)
- Sophia G. Blumenfeld (ORCID: https://orcid.org/0009-0009-3783-343X)
- Vrutti Patel (ORCID: https://orcid.org/0009-0000-5733-4229)
- Anek Jena (ORCID: https://orcid.org/0009-0003-4487-6493)
- Said Bateh (ORCID: https://orcid.org/0009-0005-9482-6093)
- Sadia Z. Shah
- Katheleen A. Rottman Pietrzak
- Shapiro Anna
Institutions
- Hospital Italiano de Buenos Aires (AR)
- WinnMed (US)
- Saint Joseph Hospital (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Journal of Intensive Care Medicine
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1177/08850666261438474
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00