Enhanced Th1 Cellular Immunity Induced by an RSV-F mRNA Vaccine Rationally Designed Using NLP Algorithms
A novel RSV PreF mRNA vaccine was successfully developed via optimization of protein structure and mRNA sequence. Superior immunogenicity was demonstrated in the BALB/c mouse model, together with promising potential in terms of vaccine safety and immunological persistence. These findings represent a promising step forward in the pursuit of an effective RSV vaccine and suggest the potential of the developed mRNA vaccine to induce substantial immune responses that may correlate with protection in future challenge studies.
Authors
- Zhi-Wu Xia
- Jia-Hao Zheng
- Junlong Zhao (ORCID: https://orcid.org/0000-0002-6148-5641)
- Guo-mei Zhang
- Min Luo (ORCID: https://orcid.org/0000-0003-4670-9712)
- Lei Zhang (ORCID: https://orcid.org/0000-0002-4880-824X)
- Yanhong Shi (ORCID: https://orcid.org/0000-0002-3938-5839)
- Jun-Jie Pan
- Chuan-Shuo Lv
- Man-Ni Xie
- Lan-Xin Jia
- Qi Tang (ORCID: https://orcid.org/0009-0006-7160-5543)
- Jing Liu
- Liang He
Institutions
- Huazhong Agricultural University (CN)
- Wuhan Institute of Bioengineering (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/vaccines14040356
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical University