Synthesis and Biological Profiling of New 1,2,3,4-Tetrahydrobenzo[h]naphthyridine-Based Hybrids as Dual Inhibitors of β-Amyloid and Tau Aggregation with Anticholinesterase Activity
, with similar or even higher Aβ42 and tau anti-aggregating activity and lower cytotoxicity than DP-128, might represent novel pharmacological tools for protein aggregation studies.
Authors
- Ana Mallo‐Abreu (ORCID: https://orcid.org/0000-0002-5092-3538)
- Jordi Juárez‐Jiménez (ORCID: https://orcid.org/0000-0003-1464-1397)
- Diego Muñoz‐Torrero (ORCID: https://orcid.org/0000-0002-8140-8555)
- Anna Sampietro (ORCID: https://orcid.org/0000-0002-1837-2051)
- Raimon Sabaté (ORCID: https://orcid.org/0000-0003-3894-2362)
- Belén Pérez (ORCID: https://orcid.org/0000-0001-5801-1704)
- Jose Manuel Brea (ORCID: https://orcid.org/0000-0002-5523-1979)
- Manuela Bartolini (ORCID: https://orcid.org/0000-0002-2890-3856)
- Rosaria Spagnuolo (ORCID: https://orcid.org/0009-0002-0289-6763)
- Carles Galdeano
- María Isabel Loza
- Aldrick B. Verano (ORCID: https://orcid.org/0000-0003-0958-8421)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universidade de Santiago de Compostela (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Institute for Research in Biomedicine (ES)
- Universitat de Barcelona (ES)
- University of Bologna (IT)
Publication Details
- Journal
- Biomolecules
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/biom16040593
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Regional Development Fund
- Agencia Estatal de Investigación