Zwitterionic Mn(III)‐Tetraphenyl Porphyrins: Water‐Soluble MRI Contrast Agents with High Relaxivity
-relaxivity, comparable to current clinical high-relaxivity GBCAs like gadopiclenol. In addition, zwitterionic complexes Mn-8 and Mn-9 have superior relaxivity and improved stability compared to Mn-DPDP (mangafodipir, Teslascan). The favorable properties of both compounds can be attributed to the decoration of the chelator with sulfobetaines or N-oxides. Importantly, chelation of Mn(III) by the porphyrin drastically reduces singlet oxygen generation. Mn-8 showed good contrast enhancement in vivo. These compounds are thus strong candidates for the development of next-generation gadolinium-free MRI contrast agents.
Authors
- Markus Fischer (ORCID: https://orcid.org/0000-0001-7243-4199)
- Marie Oest (ORCID: https://orcid.org/0009-0005-9351-5365)
- Neus Feliu (ORCID: https://orcid.org/0000-0002-7886-1711)
- Verena R. Schulze (ORCID: https://orcid.org/0000-0003-1533-708X)
- Wolfgang Maison (ORCID: https://orcid.org/0000-0003-2793-5722)
- Samila Leon Chaviano
- Darius Ludolfs
- John V. Frangioni
- Lennart F. V. Spickschen
- Stefanie Bredehöft
- Marc‐André Fortin
Institutions
- Universität Hamburg (DE)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- Flow Pharma (United States) (US)
- Hôtel-Dieu de Québec (CA)
- Fraunhofer Institute for Applied Polymer Research (DE)
- Hamburg Institut (Germany) (DE)
- Centre hospitalier de l'Université Laval (CA)
- Université Laval (CA)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1002/cmdc.70268
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fraunhofer-Gesellschaft
- Universität Hamburg