A Metal‐Free and Site‐Selective Isothiocyanation of the Allyl C(sp <sup>3</sup> )‐H Bond
Herein, we reported a site‐selective isothiocyanation of allyl C(sp 3 )‐H bonds. Through the hypervalent iodine reagents promotion strategy, selective isothiocyanation of allyl C(sp 3 )‐H bonds in simple cyclic olefins and natural steroid molecules was realized. This method features high site‐selectivity, good functional group tolerance, metal‐free and mild reaction conditions.
Authors
- Jingyu Meng (ORCID: https://orcid.org/0000-0003-4149-111X)
- Xiaoqian Shen (ORCID: https://orcid.org/0000-0001-6284-520X)
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Ruixue Ji
- S. Qian
- Zhong‐Quan Liu (ORCID: https://orcid.org/0000-0001-6961-0585)
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1002/adsc.70419
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China